Brain, Computation and Data-science

Neurophysiological Screening of Learning Disability and Evaluation of Cognitive Decline in the Elderly using a novel EEG Band 

A novel EEG band with the integrated signal acquisition and conditioning circuits is proposed. This is ergonomic, easy to wear and subject-friendly allowing accurate monitoring of brain wellness.

Neuro-protective Intervention in a Realistic, Neurophysiological Model of Stroke in Rats

We propose a stringent model of Stroke using robust, well-studied neurophysiological metrics in a physiologically realistic rat 4-vessel occlusion model. Using the mono-phasic population responses in the lateral corticospinal tracts post-primary motor cortical stimulation, we will identify the kinetics of acute Stroke and dissect ionic dysfunction using ionic channel blockers, e.g. TTX. There is evidence that proteases are activated in neural insults, e.g., in Spinal Cord Injury, Stroke, etc. We will pilot a preliminary neuro-protective intervention using a non-specific Serine Protease inhibitor to block apoptotic pathways in Stroke.

Bioresorbable Sensor to Record ECG and ECoG for Clinical Applications

Implantable electronic modules are used in modern clinical practice for continuous monitoring of biopotentials. The implanted module may act as a source of infection. Surgical retrieval procedure that involves re-operative steps leading to more trauma and possible complications. Bioresorbable materials get dissolved in body fluids based on pH and temperature conditions. Thus, such materials can be used to reengineer new electronic modules that use sensors that get resorbed within the body eliminating the shortcomings that kept many of these promising technologies at bay.

Combining NIRS and Electrophysiology to evaluate cognition in Schizophrenia and Screen for Congenital Deafness in Newborns

Around 1% of world population suffers from Schizophrenia. There are multiple drugs available in the market for treating Schizophrenic patients. Consequently, there is an urgent need to quickly identify which drugs are effective. Many infants are born with congenital deafness that needs to be diagnosed as early as possible, so that effective interventions can be introduced immediately. As the infants are unable to communicate the neurocognition ability by their own there is a need of a simple, reliable and robust device to identify deafness in the new-born including their neuro-cognition ability.

The portable fNIRS-EEG band will include Optodes (for fNIRS) to detect the infrared spectroscopic quantitative measurements of the oxygenated and deoxygenated blood flowing in a particular part of the brain. Additionally, the EEG electrodes will measure the electrical signals in the same part of the brain. The combined fNIRS-EEG portable band will give a higher temporal and spatial resolution which is expected to identify the most effective therapeutic regime for individual Schizophrenic patients, and diagnose neuro-cognition ability of the infants