Our Research Work

Our greatest weakness lies in giving up. The most certain way to succeed is always to try just one more time. -Thomas A. Edison

The objective of this study is to design and develop a portable tool consisting of a disposable biochip for measuring electro-thermo-mechanical (ETM) properties of a tissue. A biochip integrated with a microheater, force sensors, and electrical sensors is fabricated using microtechnology. The sensor covers the area of 2 mm and the biochip is 10 mm in diameter. A portable tool capable of holding tissue and biochip is fabricated using 3-D printing.

Atrial fibrillation (AFib) is a significant healthcare problem caused by the uneven and rapid discharge of electrical signals from pulmonary veins (PVs). The technique of radiofrequency (RF) ablation can block these abnormal electrical signals by ablating myocardial sleeves inside PVs. Catheter contact force measurement during RF ablation can reduce the rate of Afib recurrence, since it helps to determine the effective contact of the catheter with the tissue, thereby resulting in effective power delivery for ablation. We have developed a 3-D force sensor to provide the real-time measurement of triaxial catheter contact force. The 3-D force sensor consists of a plastic cubic bead and five flexible force sensors. Each flexible force sensor was made of a PEDOT:PSS strain gauge and a polydimethylsiloxsane (PDMS) bump on a flexible PDMS substrate.

A biosensor for rapid (<90 min), real time, and label-free bacteria isolation from whole blood and antibiotic susceptibility measurement. Target bacteria are captured on flexible plastic-based microchips with printed electrodes using antibodies (30 min) and its electrical response are monitored in the presence of antibiotics over an incubation of 1 h.

A micro-electro-mechanical-systems (MEMS) based flexible polymer microsensor array capable of simultaneously measuring electro-mechanical properties of the breast tissues cores (1 mm in diameter and 10 ?m in thickness) from onset through progression of the cancer.

A sensor incorporating nanostructured zinc oxide film on planar and thermally isolated MEMS platform is reported for detecting Volatile Organic Compounds (VOCs). An innovative technique for fabricating sensor having integrated microheater with improved mechanical strength is proposed. The proposed innovation facilitates the sensor to achieve desired temperature on the chip at lower power.

Mechanical phenotyping of breast cancer using MEMS: A method to demarcate benign and cancerous breast tissue.