Arise! Awake! and stop not until the goal is reached. -Swami Vivekananda
The objective of this study is to design and develop a portable tool consisting of a disposable biochip for measuring electro-thermo-mechanical (ETM) properties of a tissue. A biochip integrated with a microheater, force sensors, and electrical sensors is fabricated using microtechnology. The sensor covers the area of 2 mm and the biochip is 10 mm in diameter. A portable tool capable of holding tissue and biochip is fabricated using 3-D printing.
Atrial fibrillation (AFib) is a significant healthcare problem caused by the uneven and rapid discharge of electrical signals from pulmonary veins (PVs). The technique of radiofrequency (RF) ablation can block these abnormal electrical signals by ablating myocardial sleeves inside PVs. Catheter contact force measurement during RF ablation can reduce the rate of Afib recurrence, since it helps to determine the effective contact of the catheter with the tissue, thereby resulting in effective power delivery for ablation. We have developed a 3-D force sensor to provide the real-time measurement of triaxial catheter contact force. The 3-D force sensor consists of a plastic cubic bead and five flexible force sensors. Each flexible force sensor was made of a PEDOT:PSS strain gauge and a polydimethylsiloxsane (PDMS) bump on a flexible PDMS substrate.
A micro-electro-mechanical-systems (MEMS) based flexible polymer microsensor array capable of simultaneously measuring electro-mechanical properties of the breast tissues cores (1 mm in diameter and 10 μm in thickness) from onset through progression of the cancer.
A sensor incorporating nanostructured zinc oxide film on planar and thermally isolated MEMS platform is reported for detecting Volatile Organic Compounds (VOCs). An innovative technique for fabricating sensor having integrated microheater with improved mechanical strength is proposed. The proposed innovation facilitates the sensor to achieve desired temperature on the chip at lower power.
Mechanical phenotyping of breast cancer using MEMS: A method to demarcate benign and cancerous breast tissue
Our mission and vision
We seek to understand and exploit novel ways of fabricating microengineering devices using glass, silicon, polymers and integrate with unusual classes of micro/nanomaterials. Our aim is to integrate biology/medicine with microtechnology, nanotechnology and additive manufacturing to develop innovative tools to solve unmet clinical problems. Our current research focuses on flexible sensors, microsensors, microfluidic devices, and microelectromechanical systems, all lately with an emphasis on cancer diagnosis, therapeutics, e-nose, and biomedical device technologies. These efforts are multidisciplinary and combine expertise from different fields of technical study.
Dr. Hardik J. Pandya is an Assistant Professor in the Department of Electronic Systems Engineering, Division of Electrical Sciences, IISc Bangalore where he is developing Advanced Microsystems and Biomedical Devices Facility for Clinical Research and Biomedical and Electronic (10-6-10-9) Engineering Systems Laboratory to carry out cutting-edge research on novel devices to solve unmet problems in biology and medicine. He received the bachelor’s degree and the master’s degree (gold medalist) in electronics from Sardar Patel University, Gujarat, India, in 2002 and 2004, respectively, and the Ph.D. degree in MEMS-based sensors technology from IIT Delhi in 2013. He was a project fellow in the Department of Electronics Science, Sardar Patel University, from 2004 to 2006 and a Lecturer in the Department of Electronics and Communication Engineering, Invertis University, from 2006 to 2009, prior to beginning his Ph.D. studies. He was a Faculty Research Assistant with the Department of Mechanical Engineering, Maryland Robotics Center, University of Maryland, College Park, from 2012 to 2014, where he was a Post-Doctoral Research Associate from 2014 to 2016. In early 2016 he joined the Department of Medicine, Brigham and Women’s Hospital–Harvard Medical School affiliated with Harvard-MIT Health Science and Technology as a Post-Doctoral Research Fellow where he worked on novel 3D in vitro platforms for studying cancer therapies and point-of-care devices for infectious diseases. His research interests include integrating biology/medicine with micro- and nanotechnology to develop innovative tools to solve unmet clinical problems. His interests also include design and fabrication of microsensors for cancer diagnosis, developing 3D microfluidic platforms for studying cancer therapies, additive manufacturing for microsensor packaging, MEMS-based sensors for VOC sensing, flexible sensors and devices for biomedical robotics. His work on Simultaneous MEMS-based electro-mechanical phenotyping of breast cancer has been highlighted as “Breaking Research News” by The Physicians Committee for Responsible Medicine while his research work: Towards a Portable Cancer Diagnosis Tool Using a Disposable MEMS-based Biochip was featured on IEEE Transactions on Biomedical Engineering July 2016 issue cover image as well as IEEE Transactions on Biomedical Engineering July 2016 feature article for the website and monthly highlights. The work was also featured on Science Translational Medicine as an Editorial Choice, Breast Cancer Diagnosis, March 2016 and has been highlighted on CapeRay blog as “Biochips and Diagnostic tools” in April 2016. He has been a co-inventor in an Australian patent, has filed two U.S. patents, two Patent Cooperation Treaty (PCT), and three Indian patents in the area of biosensors, MEMS-based sensors for cancer diagnosis, and energy-efficient VOC sensors. His work has been published in high-quality journals including Lab on a Chip, IEEE Transactions on Biomedical Engineering, IEEE Journal of Microelectromechanical Systems, Sensors and Actuators B, Biosensors and Bioelectronics, Nanoscience and Nanotechnology Letters, Sensors and Transducers, and Journal of Micromechanics and Micromachining.